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IGRALZHEIMER

INVESTIGATION OF THE PHARMACOLOGICAL EFFICACY OF INSATURATED FATTY ACIDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE


According to the World Health Organization (WHO), a new case of dementia is diagnosed every 7 seconds around the world, having reached 44 million patients in 2013 and it is estimated to reach 50 million in 2020. Alzheimer´s disease (AD) is the most common cause of dementia, representing 60-80% of the cases and is the major challenge in our society at the sanitary level. Therefore, finding effective therapies is a priority.
With that purpose in mind, the project IGRALZHEIMER from RETO calling was created with several companies, with the aim to further develop several molecules that have been shown to be effective in mouse models of AD, and now commercialize them as functional-nutraceutical and advance in the development of a future medicine.
To accomplish the proposed activities, this project counts with prominent public and private companies and so, it is expected to surpass with great success the following specific objectives:
- Computational study for the prediction of new crystalline forms of the molecule under study with the purpose of improving its physical, chemical and pharmaceutical properties.
- Develop the synthesis method, scaling and quality control of the molecule under study.
- Improve the knowledge of the action mechanism.
- Develop the nutraceutical product based in the molecule under study.
- Produce development batches of the pharmaceutical product.
- Perform preclinical studies (regulatory and GLP) of bioanalysis, genotoxicity and animal models toxicity.
The project “Investigación de la eficacia farmacológica de ácidos grasos insaturados de diseño para el tratamiento de la enfermedad de Alzheimer (IGRALZHEIMER)”, RTC-2015-3542-1, has been financed by the Ministerio de Economía, Industria y Competitividad (Spain), through the Retos-Colaboración 2015 calling of the Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad from the Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016.

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