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STOP AIDS

The Praxis Group has, among its strategic lines, the application of the latest developments in Advanced Therapies for the treatment of AIDS.

HIV continues to be a major global public health issue. In 2015, an estimated 36.7 million people were living with HIV, including 1.8 million children. The vast majority of this number live in low- and middle- income countries. In the same year, 1.1 million people died of AIDS-related illnesses. Since the start of the epidemic, an estimated 78 million people have become infected with HIV and 35 million people have died of AIDS-related illnesses.

 

HIV infects T lymphocytes through the CCR5 membrane coreceptor.   The CCR5D32 is a rare alteration that affects 1% of European population.  It is known, that the persons who carry it are naturally resistant to HIV infection. In this project, Praxis Pharmaceutical intends to develop a genic therapy to reproduce the D32 mutation in the cells of persons infected by HIV to, this way, cure the infection.  The consortium, led by Praxis Pharmaceutical, is formed also by the Insitituto de Investigación del SIDA (IrsiCaixa), el Consejo Superior de Investigaciones Científicas (CSIC) and Karuna Good Cells Technologies, SL.

 

This project consists of applying the latest advances in genome editing developed and patented (Guraizeak ®) by some members of the consortium, in order to modify in vitro TCD4+ lymphocytes of persons infected by HIV in order to avoid the expression of the CCR5 protein.  During the three years of the duration of the project, it is planned to carry out in vitro experiments, as well as with animals, to determine safety and efficacy of the procedure.

 

The Project STOP-SIDA, NEW TOOLS OF GENOMIC INGENEERING FOR THE TREATMENT OF AIDS is funded by Spanish Ministry of Economy, Industry and Competitivity, through the National Programme for Research-Social Challenges in the frame of the Scientific and Technical Investigation and Innovation National Plan 2013-2016.

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